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NORTHBROOK, Ill., Nov. 17, 2015 /PRNewswire/ -- Astellas US, LLC, a subsidiary of Tokyo-based Astellas Pharma Inc. (Tokyo: 4503), today announced several abstracts, including an oral presentation on gilteritinib (ASP2215), a selective inhibitor of FLT3/AXL, in patients with relapsed or refractory (R/R) acute myeloid leukemia (AML), that will be presented at the 57th American Society of Hematology (ASH) Annual Meeting and Exposition, Dec. 5-8 in Orlando.
"We are committed to developing treatments for patients in malignant & non-malignant hematology," said Claire Thom, Pharm.D., senior vice president and oncology therapeutic head, Astellas. "Our gilteritinib development program is intended to address the unmet medical needs of AML patients, and we're pleased to present updated results from our Phase 1/2 study focusing initially on individuals with relapsed/refractory FLT3-ITD positive for AML."
The following abstract will be presented during an oral presentation session:
Title: Antileukemic Activity and Tolerability of ASP2215 80mg and Greater in FLT3 Mutation-Positive Subjects with Relapsed or Refractory Acute Myeloid Leukemia: Results from a Phase 1/2, Open-Label, Dose-Escalation/Dose-Response Study (Altman et al) (Abstract 321)
Presenter: Jessica Altman, M.D., Northwestern University's Feinberg School of Medicine
Astellas recently announced the dosing of the first patient in a randomized Phase 3 registration trial of gilteritinib versus salvage chemotherapy in patients with R/R AML. On Oct. 27, 2015, the Japanese Ministry of Health, Labor and Welfare (MHLW) announced the selection of gilteritinib as one of the first products designated for SAKIGAKE.
In addition to the oral presentation, Astellas will present the following abstracts in poster sessions:
About Acute Myeloid Leukemia
Acute myeloid leukemia is a cancer that impacts the blood and bone marrow and is most commonly experienced in older adults. According to the American Cancer Society, in 2015, there will be an estimated 20,830 new cases of AML diagnosed in the United States, and about 10,460 cases will result in death.
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